|
KMID : 0861019970120020021
|
|
Korea Journal of Herbology
1997 Volume.12 No. 2 p.21 ~ p.38
|
|
|
A study on the effects of Psoraleae Fructus in ovariectomized rat model of Postmenopausal osteoporosis
|
|
權爀泰/Kwon, Hyuk Tae
徐富一/金先熙/金美麗/Seo, Bu Il/Kim, Sun Hee/Kim, Mi Ryu
|
|
|
Abstract
|
|
|
This study was performed to investigate the effects of Psoraleae Fructus in ovariectomized osteoporosis. The rat model of osteoporosis was induced by ovariectomy of rats. And liquid extract of Psoraleae Fructus was utilized in this experiment, this extract was administered orally 1 time per day during 4 weeks. And then I measured osteocalcine, estradiol, 1, 25-Vitamin D, ALP, phosphorus, calcium of the serum and calcium, phosphorus, deoxyphridinoline of the urine.
The results of this experiment were summarized as follows:
1. In the level of serum osteocalcine, the result of Control group was 0.33±0.03ng/㎖, but the result of Psoraleae Fructus group was 0.28±0.007ng/㎖. And the result of Psoraleae Fructus group showed decrease in comparison with Control group, but this result showed no efficacy.
2. In the level of serum estradiol, the result of Control group was 12.46±1.48pg/㎖, but the result of Psoraleae Fructus group was 12.56±0.69pg/㎖. And the result of Psoraleae Fructus group showed a little increase in comparison with Control group, but this result showed no efficacy.
3. In the level of serum 1,25-Vitamin D, the result of Control group was 38.35±7.85pg/㎖, but the result of Psoraleae Fructus group was 60.15±3.99pg/㎖. And the result of Psoraleae Fructus group showed a significant increase in comparison with Control group.
4. In the level of serum ALP, the result of Control group was 14.40±1.41(K-A Unit), but the result of Psoraleae Fructus group was 15.87±1.03(K-A Unit). And the result of Psoraleae Fructus group showed a little increase in comparison with Control group, but this result showed no efficacy.
5. In the level of serum phosphorus, the result of Control group was 6.81±0.31㎎/㎗, but the result of Psoraleae Fructus group was 5.69±0.17㎎/㎗. And the result of Psoraleae Fructus group showed a significant decrease in comparison with Control group.
6. In the level of serum calcium, the result of Control group was 11.50±0.20㎎/㎗, but the result of Psoraleae Fructus group was 11.89±0.13㎎/㎗. And the result of Psoraleae Fructus group showed a increase in comparison with Control group, but this result showed no efficacy.
7. In the level of urine phosphorus, the result of Control group was 7.42±0.58㎎/day, but the result of Psoraleae Fructus group was 7.71±0.50㎎/day. And the result of Psoraleae Fructus group showed a little increase in comparison with Control group, but this result showed no efficacy.
8. In the level of urine calcium, the result of Control group was 2.03±0.37㎎/day, but the result of Psoraleae Fructus group was 0.76±0.10㎎/day. And the result of Psoraleae Fructus group showed a significant decrease in comparison with Control group.
9. In teh level of urine deoxypyridinoline, the result of Control group was 396.33±34.64nM, but the result of Psoraleae Fructus group was 345.82±35.58nM. And the result of Psoraleae Fructus group showed a decrease in comparison with Control group, but this result showed no efficacy.
According to above these results, Psoraleae Fructus has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|